Disclosure of APOE genotype for risk of Alzheimer's disease.

  title={Disclosure of APOE genotype for risk of Alzheimer's disease.},
  author={Robert C Green and J Scott Roberts and L. Adrienne Cupples and Norman Relkin and Peter J. Whitehouse and Tamsen M Brown and Susan Larusse Eckert and Melissa Barber Butson and Adele Dessa Sadovnick and Kimberly A. Quaid and Clara Chen and Robert Cook-Deegan and Lindsay A. Farrer},
  journal={The New England journal of medicine},
  volume={361 3},
BACKGROUND The apolipoprotein E (APOE) genotype provides information on the risk of Alzheimer's disease, but the genotyping of patients and their family members has been discouraged. We examined the effect of genotype disclosure in a prospective, randomized, controlled trial. METHODS We randomly assigned 162 asymptomatic adults who had a parent with Alzheimer's disease to receive the results of their own APOE genotyping (disclosure group) or not to receive such results (nondisclosure group… CONTINUE READING


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