Discerning the function of p53 by examining its molecular interactions.

  title={Discerning the function of p53 by examining its molecular interactions.},
  author={J D Oliner},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={15 11},
  • J D Oliner
  • Published 1993 in
    BioEssays : news and reviews in molecular…
Of the many genes mutated on the road to tumor formation, few have received as much attention as p53. The gene has come to occupy center stage for the simple reason that it is more frequently altered in human tumors than any other known gene, undergoing mutation at a significant rate in almost every tumor type in which it has been studied. This association between p53 mutation and tumorigenesis has spurred a flurry of research attempting to delineate the normal function of p53 and, by extension… CONTINUE READING
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