Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.

@article{Tsakiridis1994DisassemblyOT,
  title={Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.},
  author={Theodoros K Tsakiridis and Mladen Vranic and Amira Klip},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 47},
  pages={29934-42}
}
In muscle and fat tissues, insulin stimulates glucose transport through the translocation of glucose transporter proteins from an intracellular storage pool to the plasma membrane. The mechanism of this translocation is unknown. We have examined the possible role of the actin microfilament network in the stimulation of glucose transport by insulin and on the distribution of glucose transporters, in differentiated L6 rat skeletal muscle cells. Insulin (10(-7) M for 30 min) caused a major… CONTINUE READING
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