Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing

@article{SaccoBubulya2002DisassemblyOI,
  title={Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing},
  author={Paula A Sacco-Bubulya and David L. Spector},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={156},
  pages={425 - 436}
}
To examine the involvement of interchromatin granule clusters (IGCs) in transcription and pre-mRNA splicing in mammalian cell nuclei, the serine-arginine (SR) protein kinase cdc2-like kinase (Clk)/STY was used as a tool to manipulate IGC integrity in vivo. Both immunofluorescence and transmission electron microscopy analyses of cells overexpressing Clk/STY indicate that IGC components are completely redistributed to a diffuse nuclear localization, leaving no residual structure. Conversely… CONTINUE READING
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