Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin.

@article{Cherniack1995DisassemblyOS,
  title={Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin.},
  author={Andrew D Cherniack and Jes K. Klarlund and Bruce R Conway and M. Czech},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 4},
  pages={1485-8}
}
Insulin receptor signaling acutely stimulates GTP loading of p21ras, apparently by mobilizing complexes of Grb2 and the guanine nucleotide exchangers Son-of-sevenless (Sos) 1 and 2 to associate with tyrosine-phosphorylated proteins in the plasma membrane. Here we show that in 32P-labeled 3T3-L1 adipocytes the elevated cellular concentrations of [32P]GTP-bound p21ras in response to insulin return to near basal levels after 20-30 min of hormone stimulation, while insulin receptors remain… CONTINUE READING

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