Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation.

@article{Shi2008DisassemblyOM,
  title={Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation.},
  author={Wei Shi and Zhefu Ma and Henning Willers and Kamal Akhtar and Shaun P. Scott and Jiuqin Zhang and Simon Powell and Junran Zhang},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 46},
  pages={31608-16}
}
The orderly recruitment, retention, and disassembly of DNA damage response proteins at sites of damaged DNA is a conserved process throughout eukaryotic evolution. The recruitment and retention of DNA repair factors in foci is mediated by a complex network of protein-protein interactions; however, the mechanisms of focus disassembly remain to be defined. Mediator of DNA damage checkpoint protein 1 (MDC1) is an early and key component of the genome surveillance network activated by DNA double… CONTINUE READING