Disassembling Protein Aggregates in the Yeast Cytosol

@article{Haslbeck2005DisassemblingPA,
  title={Disassembling Protein Aggregates in the Yeast Cytosol},
  author={Martin Haslbeck and Anita Miess and Thusnelda Stromer and Stefan Walter and Johannes Buchner},
  journal={Journal of Biological Chemistry},
  year={2005},
  volume={280},
  pages={23861 - 23868}
}
In all organisms studied, elevated temperatures induce the expression of a variety of stress proteins, among them small Hsps (sHsp). sHsps are chaperones that prevent the unspecific aggregation of proteins by forming stable complexes with unfolded polypeptides. Reactivation of captured proteins requires the assistance of other ATP-dependent chaperones. How sHsps and ATP-dependent chaperones work together is poorly understood. Here, we analyzed the interplay of chaperones present in the cytosol… Expand
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TLDR
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TLDR
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TLDR
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