Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo.

@article{Ireland2014DisarmingBP,
  title={Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo.},
  author={Philip M. Ireland and R{\'o}is{\'i}n M McMahon and Laura Emma Marshall and Maria A. Halili and Emily Jane Furlong and Stephanie V Tay and Jennifer L. Martin and Mitali Sarkar-Tyson},
  journal={Antioxidants & redox signaling},
  year={2014},
  volume={20 4},
  pages={
          606-17
        }
}
AIMS The intracellular pathogen Burkholderia pseudomallei causes the disease melioidosis, a major source of morbidity and mortality in southeast Asia and northern Australia. The need to develop novel antimicrobials is compounded by the absence of a licensed vaccine and the bacterium's resistance to multiple antibiotics. In a number of clinically relevant Gram-negative pathogens, DsbA is the primary disulfide oxidoreductase responsible for catalyzing the formation of disulfide bonds in secreted… CONTINUE READING
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