Disappearing "T1 black holes" in an animal model of multiple sclerosis.

  title={Disappearing "T1 black holes" in an animal model of multiple sclerosis.},
  author={I. Pirko and A. J. Johnson and Jeff D. Gamez and Slobodan Macura and Moses Rodriguez},
  journal={Frontiers in bioscience : a journal and virtual library},
Brain MRI in multiple sclerosis (MS) frequently shows areas of hypointensity in the white matter on T1 weighted sequences ("T1 black holes"). These areas are thought to be consistent with irreversible axonal loss. In this study T1 black holes were characterized in Theiler's Murine Encephalitis Virus infection, an established model of demyelinating diseases in mice. The spectrum of TMEV is broad in different strains. C57BL/6J mice develop a self-limited brain disease, which resolves within 4-6… CONTINUE READING