Disappearance of slan-positive non-classical monocytes for diagnosis of chronic myelomonocytic leukemia with an associated inflammatory state

  title={Disappearance of slan-positive non-classical monocytes for diagnosis of chronic myelomonocytic leukemia with an associated inflammatory state},
  author={Sihem Tarfi and Bouchra Badaoui and Nicolas Freynet and Margot Morabito and Jeffie Lafosse and Andr{\'e}a Toma and Gabriel {\'E}tienne and Jean-Baptiste Micol and Ivan Sloma and Pierre Fenaux and Eric Solary and Doroth{\'e}e S{\'e}limoglu-Buet and Orianne Wagner-Ballon},
  pages={e147 - e152}
The diagnosis of chronic myelomonocytic leukemia (CMML) relies on both a persistent peripheral blood monocytosis (monocytes ≥1x10/L) and monocytes accounting for ≥10% of the white blood cell (WBC) differential count. We showed that a relative accumulation of classical monocytes (cMo: CD14CD16) ≥94% among the total peripheral blood monocytes measured by flow cytometry could help to distinguish CMML from other causes of monocytosis. Since then, the quantification of circulating monocyte subsets… 

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