Disappearance of low affinity adenosine binding sites in aging rat cerebral cortex and hippocampus.

Abstract

A1 adenosine receptor binding was investigated, using the selective agonist, [3H]cyclohexyladenosine, on membranes prepared from the cerebral cortex and hippocampus of 3- and 24-month-old rats. The Scatchard analysis of the binding results obtained in the cerebral cortex of young animals showed two distinct binding sites with apparent Kd of 2 and 24 nM and… (More)

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