Disappearance of gadolinium enhancement in a chemoresistant astrocytoma of the tectum after high-dose interferon beta.

@article{Matsuno2008DisappearanceOG,
  title={Disappearance of gadolinium enhancement in a chemoresistant astrocytoma of the tectum after high-dose interferon beta.},
  author={Akira Matsuno and Takamitsu Fujimaki and Akiko Mizutani and Fuyuaki Ide and Hideki Tanaka and S. Asano and Satoru Miyawaki and Takeshi Uno and Junichi Tanaka and Hiroshi Nakaguchi and Mitsuyoshi Sasaki and Mineko Murakami and Kazuto Yamazaki and Yasuo Ishida},
  journal={Tumori},
  year={2008},
  volume={94 6},
  pages={853-5}
}
Interferon beta 6 million units per week was administered to a patient with an aggressive astrocytoma in the tectum that was resistant to cisplatin, etoposide, vinblastine, and the oral alkylating agent temozolomide. The tumor was immunopositive for O6-methylguanine-DNA methyltransferase (MGMT). Interferon beta caused the disappearance of the gadolinium-enhanced lesion in the tectum. Interferons have apoptotic and antiangiogenic effects on tumor cells, and the lesion's disappearance may have… CONTINUE READING