Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval.

@article{Koenig1989DisappearanceAR,
  title={Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval.},
  author={Jane H. Koenig and Kazuo Ikeda},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1989},
  volume={9 11},
  pages={3844-60}
}
The temperature-sensitive mutant of Drosophila, shibire(ts-1), which is normal at 19 degrees C, but in which endocytosis is reversibly blocked at 29 degrees C, was used to deplete synapses of vesicles by inducing transmitter release while membrane retrieval was blocked. When the synapse was kept at 29 degrees C for 8 min, complete vesicle depletion occurred. However, no compensatory increase in the terminal plasma membrane, either as invaginations or evaginations, was observed. Also, no… CONTINUE READING
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