Disaggregation of in vitro preformed platelet-rich clots by abciximab increases fibrin exposure and promotes fibrinolysis.

@article{Collet2001DisaggregationOI,
  title={Disaggregation of in vitro preformed platelet-rich clots by abciximab increases fibrin exposure and promotes fibrinolysis.},
  author={J. P. Collet and Gilles Montalescot and Claude Lesty and Jeannette Soria and Zohair Mishal and Dani{\`e}l Thomas and C. I. M. A. Arturo Soria},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 1},
  pages={142-8}
}
The glycoprotein IIb/IIIa receptor inhibitor abciximab has been shown to facilitate the rate and the extent of pharmacological thrombolysis with recombinant tissue plasminogen activator (rtPA) in patients with acute myocardial infarction. However, the underlying mechanisms remain not fully determined. We sought to demonstrate that this facilitating effect of abciximab could be related to its potential to modify the clot architecture and the clot physical properties. Compared with fibrin-rich… CONTINUE READING

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