Disaggregation of Aggregated Platelets by Savignygrin, a αIIbβ3 Antagonist from Ornithodoros Savignyi

  title={Disaggregation of Aggregated Platelets by Savignygrin, a $\alpha$IIb$\beta$3 Antagonist from Ornithodoros Savignyi},
  author={B. Mans and A. Louw and A. Neitz},
  journal={Experimental \& Applied Acarology},
Ticks control their host's hemostatic system by secretion of bioactive components during feeding that inhibit blood coagulation and platelet aggregation. Dissolution of platelets that have already aggregated can enhance control over the hemostatic system. It has been shown that disaggregation of aggregated platelets by the enzyme apyrase was accompanied by a shape change from the aggregated spherical form back to the discoid form associated with un-activated platelets. The present study… Expand

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