Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors.

@article{Marchant1997DisaccharidePB,
  title={Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors.},
  author={J. Marchant and M. Beecroft and A. Riley and D. Jenkins and R. D. Marwood and C. Taylor and B. Potter},
  journal={Biochemistry},
  year={1997},
  volume={36 42},
  pages={
          12780-90
        }
}
  • J. Marchant, M. Beecroft, +4 authors B. Potter
  • Published 1997
  • Chemistry, Medicine
  • Biochemistry
  • The glyconucleotides adenophostin A and B are the most potent known agonists at type 1 inositol trisphosphate [Ins(1,4,5)P3] receptors, although their stuctures differ markedly from that of Ins(1,4,5)P3. Equilibrium competition binding with [3H]Ins(1,4,5)P3 and unidirectional 45Ca2+ flux measurements were used to examine the effects of adenophostin A in hepatocytes, which express predominantly type 2 Ins(1,4,5)P3 receptors. Both Ins(1,4,5)P3 (Kd = 8.65 +/- 0.98 nM) and adenophostin A (Kd = 0.87… CONTINUE READING
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