Disaccharide analysis of chondroitin and heparin from farmed Atlantic salmon

@article{Flengsrud2016DisaccharideAO,
  title={Disaccharide analysis of chondroitin and heparin from farmed Atlantic salmon},
  author={R. Flengsrud},
  journal={Glycoconjugate Journal},
  year={2016},
  volume={33},
  pages={121-123}
}
  • R. Flengsrud
  • Published 2016
  • Chemistry, Medicine
  • Glycoconjugate Journal
The heparin disaccharides detected in farmed Atlantic salmon (Salmo salar) gills and intestines have, with one exception, been reported in porcine heparin. The relative amounts of disaccharides appear to be very different in the two species. Two chondroitin disaccharides with a proposed essential role in the zebrafish (Danio rerio) development and differentiation are detected in farmed Atlantic salmon. In addition, most of the chondroitin/dermatan sulfate and heparin disaccharides detected here… Expand
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References

SHOWING 1-9 OF 9 REFERENCES
Isolation and structural characterization of chondroitin sulfate from bony fishes.
Chondroitin sulfate (CS) was purified from the bones of common fishes, monkfish, cod, spiny dogfish, salmon and tuna, and characterized in an effort to find alternative sources and new peculiarExpand
Structural characterization of glycosaminoglycans from zebrafish in different ages
TLDR
GAGs were isolated and purified from zebrafish in different stages in development ranging from 0.5 days to adult and the content and disaccharide composition of chondroitin sulfate and heparan sulfate were determined using chemical assays, liquid chromotography and mass spectrometry. Expand
Purification, characterization and in vivo studies of salmon heparin.
TLDR
Results indicate that in vivo half-life time of salmon heparin was higher than that of dalteparin, and NMR-analysis detected N- and O-sulfated oligosaccharides essential forHeparin activity. Expand
Anticoagulant motifs of marine sulfated glycans
  • V. Pomin
  • Chemistry, Medicine
  • Glycoconjugate Journal
  • 2014
TLDR
The objective of this report is to present the anticoagulant motifs of the marine SFs, SGs and GAGs, which do not bear within their polymeric chains the specific pentasaccharide motif of heparin. Expand
Evolutionary Differences in Glycosaminoglycan Fine Structure Detected by Quantitative Glycan Reductive Isotope Labeling*
TLDR
This new method provides more robust, reliable, and sensitive means of quantitative evaluation of glycosaminoglycan disaccharide compositions than existing techniques allowing us to compare the chondroitin and heparan sulfate compositions of Hydra vulgaris, Drosophila melanogaster, Caenorhabditis elegans, and mammalian cells. Expand
Heparin-protein interactions.
TLDR
This review focuses on aspects of heparin structure and conformation, which are important for its interactions with proteins, and describes the interaction ofheparin and heparan sulfate with selected families of heParin-binding proteins. Expand
Perspective on the Use of Sulfated Polysaccharides from Marine Organisms as a Source of New Antithrombotic Drugs
TLDR
If these aspects are successfully addressed, sulfated polysaccharides from marine organisms may conquer the frontier of antithrombotic therapy and open new avenues for treatment or prevention of thromboembolic diseases. Expand
A Systems Biology Approach for the Investigation of the Heparin/Heparan Sulfate Interactome*
TLDR
Investigating the functional and structural properties that characterize HS-interacting proteins and the network they form revealed that heparin/HS-binding proteins form a highly interconnected network that is functionally linked to physiological and pathological processes that are characteristic of higher organisms. Expand
The binding of pentapeptides to biological and synthetic high affinity heparin.
TLDR
Pentapeptides showed an effect on in vitro heparin anti-factor X activity with a reduction of fondaparinux activity by 65-95% and was further studied by using peptide solid phase chromatography and NMR analysis. Expand