Disabling surveillance: bacterial type III secretion system effectors that suppress innate immunity.

@article{Espinosa2004DisablingSB,
  title={Disabling surveillance: bacterial type III secretion system effectors that suppress innate immunity.},
  author={Avelina Espinosa and James R. Alfano},
  journal={Cellular microbiology},
  year={2004},
  volume={6 11},
  pages={1027-40}
}
Many Gram-negative bacterial pathogens of plants and animals are dependent on a type III protein secretion system (TTSS). TTSSs translocate effector proteins into host cells and are capable of modifying signal transduction pathways. The innate immune system of eukaryotes detects the presence of pathogens using specific pathogen recognition receptors (PRRs). Plant PRRs include the FLS2 receptor kinase and resistance proteins. Animal PRRs include Toll-like receptors and nucleotide-binding… CONTINUE READING