Disabled-2 small interfering RNA modulates cellular adhesive function and MAPK activity during megakaryocytic differentiation of K562 cells.

@article{Tseng2003Disabled2SI,
  title={Disabled-2 small interfering RNA modulates cellular adhesive function and MAPK activity during megakaryocytic differentiation of K562 cells.},
  author={C P Tseng and Chien-Ling Huang and C H Huang and J Cheng and Arnold Stern and Chin-Hsiao Tseng and Daniel T Chiu},
  journal={FEBS letters},
  year={2003},
  volume={541 1-3},
  pages={21-7}
}
Previous studies have shown that Disabled-2 (DAB2) is up-regulated during megakaryocytic differentiation of human K562 cells. To delineate the consequences of DAB2 induction, a DNA vector-based small interfering RNA (siRNA) was designed to intervene in DAB2 expression. We found that DAB2 siRNA specifically inhibited DAB2 induction, resulting in the modulation of cell-cell adhesion and mitogen-activated protein kinase (MAPK) phosphorylation. The morphological changes and beta3 integrin… CONTINUE READING

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