Disability and prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension

@article{Myhr2001DisabilityAP,
  title={Disability and prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension},
  author={Kjell Morten Myhr and Trond Riise and Christian A Vedeler and M. W. Nortvedt and Marit Gr{\o}nning and Rune Midgard and Harald I. Nyland},
  journal={Multiple Sclerosis},
  year={2001},
  volume={7},
  pages={59 - 65}
}
Objective: To evaluate disability and prognosis in an untreated population-based incidence cohort of multiple sclerosis (MS) patients. Methods: The Expanded Disability Status Scale (EDSS) score was recorded in 220 MS patients. Disease progression was assessed by life table analysis with different endpoints and multivariate Cox regression analysis was performed for evaluation of prognostic factors. Results: The probability of being alive after 15 years was 94.8+1.8% (s.e.), of managing without a… 
Change in disability in patients with multiple sclerosis: a 20-year prospective population-based analysis
TLDR
This study emphasises the importance of long-term epidemiological studies and the development of clinically relevant measures that effectively predict outcome and can guide decisions on therapeutic management.
Contribution of different relapse phenotypes to disability in multiple sclerosis
TLDR
Relapses in pyramidal, cerebellar and bowel/bladder systems have the greatest association with disability change, and prevention of these relapses is an important objective of disease-modifying therapy.
Clinical course of multiple sclerosis: A nationwide cohort study
Background: The course of multiple sclerosis (MS) has been studied in several cohorts; however, results have varied significantly. Objective: To describe the clinical course of MS in a nationwide
Older Age at Multiple Sclerosis Onset Is an Independent Factor of Poor Prognosis: A Population-Based Cohort Study
TLDR
Late onset MS was strongly associated with poor prognosis, independent of initial disease course, in predicting the disability progression along time, and only LOMS predicted time from EDSS 4 to 6.
Disability and prognosis of relapsing remitting multiple sclerosis, is it different in Iraqi patients?
  • Z. Hasan
  • Medicine, Psychology
    Neurosciences
  • 2011
TLDR
Poor prognostic indicators were older age at onset, pyramidal and sphincter involvement at the beginning of the illness, and more relapses in the first 2 years of the illnesses.
Age at disability milestones in multiple sclerosis.
TLDR
Properties of prognosis in multiple sclerosis appears, at least to some extent, as age-dependent and not substantially affected by the initial course, be it exacerbating-remitting or progressive.
Disability and Mortality in a Cohort of Multiple Sclerosis Patients: A Reappraisal
TLDR
A recent tendency of firstly hospitalised patients having a shorter disease duration and a lower disability level is indicated, which could explain the relevant decrease both in mortality and disability.
The Prognostic Value of Initial Relapses on the Evolution of Disability in Patients with Relapsing-Remitting Multiple Sclerosis
TLDR
It is confirmed that the age at onset and the number of MS attacks during the first 2 years of MS are predictors of the evolution of the disability and the importance of using time-dependent covariates is demonstrated.
The age at onset in Multiple Sclerosis is associated with patient's prognosis.
TLDR
It is shown for the first time in Central European Slovak population that MS onset age is an early marker that is in the positive correlation with disease disability progression rate, evaluated by MSSS score.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Survival and predictors of disability in Turkish MS patients
TLDR
Primary progressive disease, mostly seen in older men with motor and sphincter involvement at onset, has a worse prognosis and may represent a distinct behavioral variant of MS.
The natural history of multiple sclerosis: a regional study with some longitudinal data.
TLDR
It is concluded that the patient's established disability level after five years of illness is a useful, but not infallible, prognostic indicator.
The natural history of multiple sclerosis: a geographically based study. 3. Multivariate analysis of predictive factors and models of outcome.
TLDR
A multivariate hierarchical analysis was used to assess the significance of several demographic and clinical factors in multiple sclerosis patients and generated predictive models which permit the calculation of the median time to DSS 6 for patients with a given set of covariates.
RELAPSES AND PROGRESSION OF DISABILITY IN MULTIPLE SCLEROSIS
TLDR
The time course of progressive, irreversible disease among patients with the primary progressive type of multiple sclerosis was not affected by the presence or absence of superimposed relapses.
The natural history of multiple sclerosis: a geographically based study. 2. Predictive value of the early clinical course.
TLDR
The time to reach successive levels of disability defined by the Kurtzke Disability Status Scale in 1,099 MS patients followed at University Hospital, London, Canada between 1972 and 1984 is recorded.
The natural history of multiple sclerosis: a geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis.
TLDR
From clinical onset, rate of progression was faster in the PP- multiple sclerosis group than in the secondary progressive (SP)-multiple sclerosis group, and when the rates of progression from onset of the progressive phase to DSS 6, 8 and 10 were compared, SP-multiple sclerosis had a more rapid progressive phase.
Clinical aspects of multiple sclerosis in north-east Scotland with particular reference to its course and prognosis.
  • J. G. Phadke
  • Medicine, Psychology
    Brain : a journal of neurology
  • 1990
The prognosis and course of multiple sclerosis (MS) and the factors that affect them were assessed in a group of 1055 patients, representing an unselected (epidemiological) sample observed in the
Prognostic factors for survival in multiple sclerosis: a longitudinal, population based study in Møre and Romsdal, Norway.
TLDR
Young age at onset, initial remitting clinical course, and the presence of sensory symptoms at onset were significantly associated with longer survival in patients with multiple sclerosis in Norway.
Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up.
TLDR
In patients with an acute onset, low onset age, high degree of remission at first exacerbation, symptoms from afferent nerve fibres and onset symptoms from only one region (as compared with polyregional symptoms of the central nervous system, were factors significantly associated with a favourable long-term prognosis.
...
1
2
3
4
...