Directly observed therapy to promote medication adherence in adolescent heart transplant recipients

  title={Directly observed therapy to promote medication adherence in adolescent heart transplant recipients},
  author={Michael O. Killian and Stephanie A Clifford and Mia Liza A. Lustria and Gage L Skivington and Dipankar Gupta},
  journal={Pediatric Transplantation},
HT recipients experience high levels of medication non‐adherence during adolescence. This pilot study examined the acceptability and feasibility of an asynchronous DOT mHealth application among adolescent HT recipients. The app facilitates tracking of patients’ dose‐by‐dose adherence and enables transplant team members to engage patients. The DOT application allows patients to self‐record videos while taking their medication and submit for review. Transplant staff review the videos and… 



Directly observed therapy to promote medication adherence in paediatric heart transplant recipients.

A pilot intervention study using mobile video directly observed therapy building on emerging trends in research and clinical practice pertaining to medication adherence in paediatric organ transplantation is described.

Identifying barriers to medication adherence in adolescent transplant recipients.

The PMBS and AMBS are brief and psychometrically promising scales for assessing perceived barriers to adherence in adolescent transplant recipients.

Cell phone support to improve medication adherence among solid organ transplant recipients

Cell phone support interventions may promote medication adherence among adolescents and young adults and warrants further investigation, including a randomized controlled trial to evaluate efficacy.

Medication barriers predict adolescent transplant recipients' adherence and clinical outcomes at 18-month follow-up.

Barriers to adherence are essential to address in an effort to ameliorate adherence difficulties and potentially reduce the incidence of medical complications and mortality in adolescent transplant recipients.

Medication adherence among adolescent solid‐organ transplant recipients: A survey of healthcare providers

Suggestions to improve adherence included increasing peer and family support, providing education, and incorporating technology into adherence regimens among providers of pediatric solid‐organ transplant patients.

Adherence to immunosuppressants: how can it be improved in adolescent organ transplant recipients?

Strategies for promoting adherence in adolescent transplant recipients should include developmentally appropriate models and should incorporate health-related education, motivational strategies, and behavioral skills and should be a collaborative effort between the adolescent, family and healthcare providers.

Medication Barriers and Adherence: Experiences of Pediatric Transplant Recipients.

Adolescent reports of medication barriers may offer multidisciplinary transplant teams greater clinical utility when addressing these challenges with patients and Transplant social workers and psychologists should engage adolescents and caregivers in efforts to address medication nonadherence.

Adherence and health‐related quality of life in adolescent liver transplant recipients

Assessment of HRQOL may help identify those at highest risk for behavior, emotional and school difficulties, as well as non‐adherence with post‐transplant medical regimens, and suggest patients who may benefit from intervention to promote adherence andHRQOL.

Adolescent non‐adherence: Prevalence and consequences in liver transplant recipients

The greater incidence of late acute rejection, death and re‐transplantation owing to chronic rejection in non‐adherence patients suggests that non‐ adherence is significantly associated with an increased risk of morbidity and mortality.

Digital medicine program with pediatric solid organ transplant patients: Perceived benefits and challenges

The benefits and challenges of the DMP as reported by patients, caregivers, and medical providers are explored and how technological advances offer novel methods to assess adherence, enhance medical decision‐making, and can potentially improve clinical outcomes is highlighted.