Directly auto-transplanted mesenchymal stem cells induce bone formation in a ceramic bone substitute in an ectopic sheep model

@inproceedings{Boos2011DirectlyAM,
  title={Directly auto-transplanted mesenchymal stem cells induce bone formation in a ceramic bone substitute in an ectopic sheep model},
  author={Anja M Boos and Johanna S Loew and Gloria Deschler and Andreas Arkudas and Oliver A Bleiziffer and Heinz Gulle and Adrian Dragu and Ulrich Kneser and Raymund E Horch and Justus Patrick Beier},
  booktitle={Journal of cellular and molecular medicine},
  year={2011}
}
Bone tissue engineering approaches increasingly focus on the use of mesenchymal stem cells (MSC). In most animal transplantation models MSC are isolated and expanded before auto cell transplantation which might be critical for clinical application in the future. Hence this study compares the potential of directly auto-transplanted versus in vitro expanded MSC with or without bone morphogenetic protein-2 (BMP-2) to induce bone formation in a large volume ceramic bone substitute in the sheep… CONTINUE READING
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