Directly and indirectly technetium-99m-labeled antibodies--a comparison of in vitro and animal in vivo properties.

@article{Hnatowich1993DirectlyAI,
  title={Directly and indirectly technetium-99m-labeled antibodies--a comparison of in vitro and animal in vivo properties.},
  author={Donald J. Hnatowich and George Mardirossian and Mary Rusckowski and Miklos Fogarasi and F. Virzi and Phillip L Winnard},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1993},
  volume={34 1},
  pages={109-19}
}
To investigate the in vivo and in vitro properties of 99mTc when labeled to antibodies via one direct and one indirect method, the B72.3 and C110 IgG antibodies were radiolabeled directly via stannous ion reduction and indirectly via the hydrazino nicotinamide chelator and compared in vitro and in vivo. Antibody avidity (but not immunoreactive fraction) appeared to be independent of labeling methods for both antibodies. Following stannous ion reduction, antibodies were fragmented by denaturing… CONTINUE READING

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