Directionality of heart looping: effects of Pitx2c misexpression on flectin asymmetry and midline structures.

@article{Linask2002DirectionalityOH,
  title={Directionality of heart looping: effects of Pitx2c misexpression on flectin asymmetry and midline structures.},
  author={Kersti K. Linask and Xueyan Yu and Yiping Chen and Ming-Da Han},
  journal={Developmental biology},
  year={2002},
  volume={246 2},
  pages={407-17}
}
A critical regulatory laterality gene expressed in the left side of the straight heart tube during development is Pitx2, which when mutated in humans underlies Rieger's Syndrome. Previously reported results have indicated that, when using gain-of-function and loss-of function approaches of the chick cPitx2c isoform, this results in randomization of heart looping. To determine whether Pitx2c misexpression affects downstream morphogenesis by altering the expression of specific proteins in the… CONTINUE READING

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