Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

@article{Li2003DirectionalSR,
  title={Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.},
  author={Zhongqiao Li and Michael Hannigan and Zhicheng Mo and Bo Liu and Wei Lu and Yongzhen Wu and Alan V. Smrcka and Guanqing Wu and Lin Li and Mingyao Liu and C Huang and Dianqing Wu},
  journal={Cell},
  year={2003},
  volume={114 2},
  pages={215-27}
}
Efficient chemotaxis requires directional sensing and cell polarization. We describe a signaling mechanism involving G beta gamma, PAK-associated guanine nucleotide exchange factor (PIX alpha), Cdc42, and p21-activated kinase (PAK) 1. This pathway is utilized by chemoattractants to regulate directional sensing and directional migration of myeloid cells. Our results suggest that G beta gamma binds PAK1 and, via PAK-associated PIX alpha, activates Cdc42, which in turn activates PAK1. Thus, in… CONTINUE READING
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