Directional selection and variation in finite populations.

  title={Directional selection and variation in finite populations.},
  author={Peter D. Keightley and W G Hill},
  volume={117 3},
Predictions are made of the equilibrium genetic variances and responses in a metric trait under the joint effects of directional selection, mutation and linkage in a finite population. The "infinitesimal model" is analyzed as the limiting case of many mutants of very small effect, otherwise Monte Carlo simulation is used. If the effects of mutant genes on the trait are symmetrically distributed and they are unlinked, the variance of mutant effects is not an important parameter. If the… CONTINUE READING
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