Directional movement of rat prostate cancer cells in direct-current electric field: involvement of voltagegated Na+ channel activity.

@article{MBA2001DirectionalMO,
  title={Directional movement of rat prostate cancer cells in direct-current electric field: involvement of voltagegated Na+ channel activity.},
  author={Djamgoz MBA and Maria E. Mycielska and Zbigniew Madeja and Scott Paton Fraser and Włodzimierz Korohoda},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 14},
  pages={2697-705}
}
A two-part hypothesis has been tested, which proposes that (1) prostate cancer cells are galvanotactic (i.e. respond to an electric field by moving directionally) and (2) voltage-gated Na+ channel activity, which was shown previously to be expressed specifically by strongly metastatic cells, controls galvanotaxis. Two well-defined rat ('Dunning') cell lines, originally derived from the same prostate tumour but differing markedly in their metastatic ability, were used. Cells were exposed to… CONTINUE READING

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Expression of voltage - gated Na + channels in human prostate cancer

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