Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA.

@article{Matthews2008DirectionalMO,
  title={Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA.},
  author={Helen K. Matthews and Lorena Marchant and Carlos Carmona-Fontaine and Sei Kuriyama and Juan Larra{\'i}n and Mark Holt and Maddy Parsons and Roberto Mayor},
  journal={Development},
  year={2008},
  volume={135 10},
  pages={1771-80}
}
Directed cell migration is crucial for development, but most of our current knowledge is derived from in vitro studies. We analyzed how neural crest (NC) cells migrate in the direction of their target during embryonic development. We show that the proteoglycan Syndecan-4 (Syn4) is expressed in the migrating neural crest of Xenopus and zebrafish embryos. Loss-of-function studies using an antisense morpholino against syn4 show that this molecule is required for NC migration, but not for NC… CONTINUE READING
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