Directional evolution of Chlamydia trachomatis towards niche-specific adaptation.

@article{Borges2012DirectionalEO,
  title={Directional evolution of Chlamydia trachomatis towards niche-specific adaptation.},
  author={V{\'i}tor Borges and Alexandra Nunes and Rita Ferreira and Mar{\'i}a Jos{\'e} Palma Borrego and Jo{\~a}o V. P. Gomes},
  journal={Journal of bacteriology},
  year={2012},
  volume={194 22},
  pages={
          6143-53
        }
}
On behalf of the host-pathogen "arms race," a cutting-edge approach for elucidating genotype-phenotype relationships relies on the identification of positively selected loci involved in pathoadaptation. We studied the obligate intracellular bacterium Chlamydia trachomatis, for which same-species strains display a nearly identical core and pan genome, while presenting a wide range of tissue tropism and ecological success. We sought to evaluate the evolutionary patterns underlying species… CONTINUE READING

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