Directional cell movement through tissues is controlled by exosome secretion

@inproceedings{Sung2015DirectionalCM,
  title={Directional cell movement through tissues is controlled by exosome secretion},
  author={Bong Hwan Sung and Tatiana Ketova and Daisuke Hoshino and Andries Zijlstra and Alissa M. Weaver},
  booktitle={Nature communications},
  year={2015}
}
Directional cell movement through tissues is critical for multiple biological processes and requires maintenance of polarity in the face of complex environmental cues. Here we use intravital imaging to demonstrate that secretion of exosomes from late endosomes is required for directionally persistent and efficient in vivo movement of cancer cells. Inhibiting exosome secretion or biogenesis leads to defective tumour cell migration associated with increased formation of unstable protrusions and… CONTINUE READING
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