Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition.

@article{Lee2013DirectingSC,
  title={Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition.},
  author={Junmin Lee and Amr A Abdeen and Douglas Zhang and Kristopher A Kilian},
  journal={Biomaterials},
  year={2013},
  volume={34 33},
  pages={8140-8}
}
There is a dynamic relationship between physical and biochemical signals presented in the stem cell microenvironment to guide cell fate determination. Model systems that modulate cell geometry, substrate stiffness or matrix composition have proved useful in exploring how these signals influence stem cell fate. However, the interplay between these physical and biochemical cues during differentiation remains unclear. Here, we demonstrate a microengineering strategy to vary single cell geometry… CONTINUE READING
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