Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting

@inproceedings{Muthana2015DirectingCT,
  title={Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting},
  author={Munitta Muthana and Aneurin J. Kennerley and Rebekka S. Hughes and Ester Fagnano and Jay B. Richardson and Melanie Paul and Craig Murdoch and Fiona Louise Wright and Christopher J. Payne and Mark F. Lythgoe and Neil Farrow and Jon Dobson and J. Conner and Jim M. Wild and Claire Elizabeth Lewis},
  booktitle={Nature communications},
  year={2015}
}
Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites in mice. To achieve this, we magnetically label macrophages with super-paramagnetic iron oxide nanoparticles and apply… CONTINUE READING
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