Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

@inproceedings{Harr2015DirectedTO,
  title={Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins},
  author={Jennifer C. Harr and Teresa Romeo Luperchio and Xianrong Wong and E Suzanne Cohen and Sarah J. Wheelan and K. V. Vinodkumar V. Lokeswara Reddy},
  booktitle={The Journal of cell biology},
  year={2015}
}
Nuclear organization has been implicated in regulating gene activity. Recently, large developmentally regulated regions of the genome dynamically associated with the nuclear lamina have been identified. However, little is known about how these lamina-associated domains (LADs) are directed to the nuclear lamina. We use our tagged chromosomal insertion site system to identify small sequences from borders of fibroblast-specific variable LADs that are sufficient to target these ectopic sites to the… CONTINUE READING
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