Directed selection of MIP-1α neutralizing CCR5 antibodies from a phage display human antibody library

@article{Osbourn1998DirectedSO,
  title={Directed selection of MIP-1$\alpha$ neutralizing CCR5 antibodies from a phage display human antibody library},
  author={J. Osbourn and J. Earnshaw and K. S. Johnson and M. Parmentier and V. Timmermans and J. McCafferty},
  journal={Nature Biotechnology},
  year={1998},
  volume={16},
  pages={778-781}
}
The seven trans-membrane chemokine receptor CCR-5 is a coreceptor for macrophage tropic HIV-1 strains. CCR-5 responds to a number of chemokines, including macrophage inflammatory protein (MIP)-1α. We describe the use of MIP-1α in a biotin tyramine-mediated proximity selection to guide the selection of CCR-5-specific phage antibodies from a large phage display human library. Proximity based selections resulted in a population of antibodies recognizing CCR-5 on primary CD4+ lymphocytes, none of… Expand

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References

SHOWING 1-10 OF 17 REFERENCES
Directing phage selections towards specific epitopes.
...
1
2
...