Directed pharmacological therapy of ambiguous genitalia due to an androgen receptor gene mutation.

@article{Ong1999DirectedPT,
  title={Directed pharmacological therapy of ambiguous genitalia due to an androgen receptor gene mutation.},
  author={Yik Chiat Ong and H. B. Wong and Ganesan P Adaikan and Eu Leong Yong},
  journal={Lancet},
  year={1999},
  volume={354 9188},
  pages={1444-5}
}
We report a 46,XY infant with an M807T mutation in his androgen receptor that abrogated cellular responses to testosterone, but not to dihydrotestosterone (DHT), resulting in ambiguous genitalia. Treatment with a topical DHT gel restored male genital development allowing the infant to be reared in accordance with his chromosomal sex.