Directed ortho-metalation-cross-coupling strategies. One-pot Suzuki reaction to biaryl and heterobiaryl sulfonamides.

Abstract

A general synthesis of stable ortho-boropinacolato aryl and heteroaryl sulfonamides by directed ortho-metalation (DoM) and either MeOBPin or i-PrOBpin electrophile quench, 3 → 4, is described. A one-pot metalation-Suzuki cross-coupling procedure for the synthesis of biaryls and heterobiaryls, 3 → 5, and a complementary DoM-Ir-catalyzed boronation sequence… (More)
DOI: 10.1021/ol201175g

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Cite this paper

@article{Schneider2011DirectedOS, title={Directed ortho-metalation-cross-coupling strategies. One-pot Suzuki reaction to biaryl and heterobiaryl sulfonamides.}, author={C{\'e}dric Schneider and Ellen Broda and Victor Snieckus}, journal={Organic letters}, year={2011}, volume={13 14}, pages={3588-91} }