Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.

Abstract

Cell signaling depends on dynamic protein-protein interaction (PPI) networks, often assembled through modular domains each interacting with multiple peptide motifs. This complexity raises a conceptual challenge, namely to define whether a particular cellular response requires assembly of the complete PPI network of interest or can be driven by a specific… (More)
DOI: 10.1016/j.molcel.2014.05.002

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