Directed mutagenesis of the Rickettsia prowazekii pld gene encoding phospholipase D.

@article{Driskell2009DirectedMO,
  title={Directed mutagenesis of the Rickettsia prowazekii pld gene encoding phospholipase D.},
  author={Lonnie O. Driskell and Xuejie Yu and Lihong Zhang and Yan zhong Liu and Vsevolod L. Popov and David H Walker and Aimee Marie Tucker and David O. Wood},
  journal={Infection and immunity},
  year={2009},
  volume={77 8},
  pages={
          3244-8
        }
}
Rickettsia prowazekii, the causative agent of epidemic typhus, is an obligately intracytoplasmic bacterium, a lifestyle that imposes significant barriers to genetic manipulation. The key to understanding how this unique bacterium evades host immunity is the mutagenesis of selected genes hypothesized to be involved in virulence. The R. prowazekii pld gene, encoding a protein with phospholipase D activity, has been associated with phagosomal escape. To demonstrate the feasibility of site-directed… CONTINUE READING

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