Directed expression of simian virus 40 T-antigen in transgenic mice using the epidermal growth factor gene promoter.

@article{Pascall1994DirectedEO,
  title={Directed expression of simian virus 40 T-antigen in transgenic mice using the epidermal growth factor gene promoter.},
  author={I C Pascall and M. Azim Surani and Sheila C. Barton and Tristan J Vaughan and Kevin Brown},
  journal={Journal of molecular endocrinology},
  year={1994},
  volume={12 3},
  pages={313-25}
}
A transgenic mouse line (EGF/Tag) has been established in which expression of SV40 T-antigen is directed by a 5.5 kb fragment of the 5'-flanking region of the mouse epidermal growth factor (EGF) gene. Of the two principal sites of EGF expression in mice, submaxillary gland and kidney, T-antigen mRNA and protein were detected in the former but not in the latter tissue of the EGF/Tag animals. T-antigen expression in the submaxillary gland was restricted to the EGF-producing cells of the granular… CONTINUE READING