Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.

@article{Alvarado2014DirectedEO,
  title={Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.},
  author={David M. Alvarado and Pierre A Coulombe},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 28},
  pages={19435-47}
}
The crucial role of structural support fulfilled by keratin intermediate filaments (IFs) in surface epithelia likely requires that they be organized into cross-linked networks. For IFs comprised of keratins 5 and 14 (K5 and K14), which occur in basal keratinocytes of the epidermis, formation of cross-linked bundles is, in part, self-driven through cis-acting determinants. Here, we targeted the expression of a bundling-competent KRT5/KRT8 chimeric cDNA (KRT8bc) or bundling-deficient wild type… CONTINUE READING
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