Directed evolution of oxygenases: screening systems, success stories and challenges.

  title={Directed evolution of oxygenases: screening systems, success stories and challenges.},
  author={K. L. Tee and U. Schwaneberg},
  journal={Combinatorial chemistry & high throughput screening},
  volume={10 3},
  • K. L. Tee, U. Schwaneberg
  • Published 2007
  • Biology, Medicine
  • Combinatorial chemistry & high throughput screening
  • The field of directed evolution of oxygenases (mono-, di- and epoxygenases) is rapidly advancing as an increasing number of success stories indicate. A significant number of screening systems have been developed to specifically improve oxygenase properties. Oxygenases will become very valuable biocatalysts for synthetic applications in industry when stability, cofactor and activity properties match industrial demands. This review summarizes screening systems and principles of screening systems… CONTINUE READING
    81 Citations

    Topics from this paper

    Directed evolution 2.0: improving and deciphering enzyme properties.
    • 66
    • PDF
    Fluorescent Assay for Directed Evolution of Perhydrolases
    • 16
    Tuning P450 Enzymes as Oxidation Catalysts
    • 215
    • PDF
    Engineered proteins: redox properties and their applications.
    • 37
    • PDF
    A High-Throughput Screening Method to Reengineer DNA Polymerases for Random Mutagenesis
    • 9