Directed differentiation of mouse embryonic stem cells into pancreatic-like or neuronal- and glial-like phenotypes.

@article{McKiernan2007DirectedDO,
  title={Directed differentiation of mouse embryonic stem cells into pancreatic-like or neuronal- and glial-like phenotypes.},
  author={Eadaoin McKiernan and Lorraine O'Driscoll and Michael Kasper and Niall W Barron and Finbarr O'Sullivan and Martin M. Clynes},
  journal={Tissue engineering},
  year={2007},
  volume={13 10},
  pages={
          2419-30
        }
}
The derivation of definitive endoderm and in particular endocrine cell types from undifferentiated embryonic stem (ES) cells remains difficult to achieve. In this study, we investigated the potential to regulate the differentiation of ES cells into endodermal derivatives using extracellular factors previously associated with various aspects of pancreatic development. Feeder-free-cultured mouse ESD3 cells were manipulated to form embryoid bodies (EBs) in the presence of retinoic acid (RA). RA… CONTINUE READING
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