Directed differentiation of human embryonic stem cells into functional hepatic cells.

@article{Cai2007DirectedDO,
  title={Directed differentiation of human embryonic stem cells into functional hepatic cells.},
  author={Jun Cai and Yang Zhao and YanXia Liu and Fei Ye and Zhihua Song and Han Wen Qin and Sha Meng and Yuezhou Chen and Rudan Zhou and Xijun Song and Yushan Guo and Mingxiao Ding and Hongkui Deng},
  journal={Hepatology},
  year={2007},
  volume={45 5},
  pages={1229-39}
}
UNLABELLED The differentiation capacity of human embryonic stem cells (hESCs) holds great promise for therapeutic applications. We report a novel three-stage method to efficiently direct the differentiation of human embryonic stem cells into hepatic cells in serum-free medium. Human ESCs were first differentiated into definitive endoderm cells by 3 days of Activin A treatment. Next, the presence of fibroblast growth factor-4 and bone morphogenetic protein-2 in the culture medium for 5 days… CONTINUE READING
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