Directed differentiation of bone marrow derived mesenchymal stem cells into bladder urothelium.

@article{Anumanthan2008DirectedDO,
  title={Directed differentiation of bone marrow derived mesenchymal stem cells into bladder urothelium.},
  author={Govindaraj Anumanthan and John H Makari and Lindsey Honea and John Charles Thomas and Marcia L. Wills and Neil A. Bhowmick and M. C. Adams and Simon W Hayward and Robert J. Matusik and John W. Brock and John C. Pope},
  journal={The Journal of urology},
  year={2008},
  volume={180 4 Suppl},
  pages={1778-83}
}
PURPOSE We have previously reported that embryonic rat bladder mesenchyma has the appropriate inductive signals to direct pluripotent mouse embryonic stem cells toward endodermal derived urothelium and develop mature bladder tissue. We determined whether nonembryonic stem cells, specifically bone marrow derived mesenchymal stem cells, could serve as a source of pluripotent or multipotent progenitor cells. MATERIALS AND METHODS Epithelium was separated from the mesenchymal shells of embryonic… CONTINUE READING
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