Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells.

@article{Hu2016DirectedDO,
  title={Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells.},
  author={Yao Hu and Zhuang-Yin Qu and Shi-Ying Cao and Qi Li and Lixiang Ma and Robert Krencik and Min Xu and Yan Liu},
  journal={Journal of neuroscience methods},
  year={2016},
  volume={266},
  pages={
          42-9
        }
}
BACKGROUND Basal forebrain cholinergic neurons (BFCNs) play critical roles in learning, memory and cognition. Dysfunction or degeneration of BFCNs may connect to neuropathology, such as Alzheimer's disease, Down's syndrome and dementia. Generation of functional BFCNs may contribute to the studies of cell-based therapy and pathogenesis that is related to learning and memory deficits. NEW METHOD Here we describe a detail method for robust generation of BFCNs from human embryonic stem cells… CONTINUE READING
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