Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons.

@article{Lee2007DirectedDA,
  title={Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons.},
  author={Hyojin Lee and George Al Shamy and Yechiel Elkabetz and Claude M. Schofield and Neil L Harrsion and Georgia Panagiotakos and Nicholas D. Socci and Viviane S Tabar and Lorenz P Studer},
  journal={Stem cells},
  year={2007},
  volume={25 8},
  pages={1931-9}
}
Motoneurons represent a specialized class of neurons essential for the control of body movement. Motoneuron loss is the cause of a wide range of neurological disorders including amyotrophic lateral sclerosis and spinal muscular atrophy. Embryonic stem cells are a promising cell source for the study and potential treatment of motoneuron diseases. Here, we present a novel in vitro protocol of the directed differentiation of human embryonic stem cells (hESCs) into engraftable motoneurons. Neural… CONTINUE READING
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