Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs.

@article{Schopman2012DirectedHE,
  title={Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs.},
  author={Nick C. T. Schopman and Anja K Braun and Ben Berkhout},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 1},
  pages={479-86}
}
Despite the success of antiretroviral drugs in decreasing AIDS-related mortality, a substantial fraction of HIV-infected patients experience therapy failure due to the emergence of drug-resistant virus variants. For durable inhibition of HIV-1 replication, the emergence of such escape viruses must be controlled. In addition to antiretroviral drugs, RNA… CONTINUE READING