Direct visualization of the subthalamic nucleus and its iron distribution using high-resolution susceptibility mapping.

@article{Schaefer2012DirectVO,
  title={Direct visualization of the subthalamic nucleus and its iron distribution using high-resolution susceptibility mapping.},
  author={Andreas Schaefer and Birte U. Forstmann and Jane Neumann and Sam J. Wharton and A. Mietke and Richard Bowtell and Robert Turner},
  journal={Human brain mapping},
  year={2012},
  volume={33 12},
  pages={2831-42}
}
Histological studies have shown a relatively high iron concentration in the subthalamic nucleus (STN). T2- and T2*-weighted sequences have previously been used to visualize the STN in vivo. The phase information of gradient-echo images reflects the magnetic tissue properties more directly, e.g., iron is more paramagnetic than water. Unfortunately, phase images suffer from non-local effects and orientation dependency. The goal of this study is to delineate the STN more precisely using… CONTINUE READING

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