Direct visualization of effects of endothelin on the renal microvasculature.

@article{Loutzenhiser1990DirectVO,
  title={Direct visualization of effects of endothelin on the renal microvasculature.},
  author={Rodger D. Loutzenhiser and Murray Epstein and Koichi Hayashi and Caroline Horton},
  journal={The American journal of physiology},
  year={1990},
  volume={258 1 Pt 2},
  pages={
          F61-8
        }
}
The renal microvascular and hemodynamic actions of endothelin were assessed directly in isolated perfused hydronephrotic (HYD) and normal kidneys, respectively. In HYD kidneys endothelin was a potent vasoconstrictor of the afferent arteriole (AA), eliciting a threshold vasoconstrictor response at 0.01 nM (P less than 0.05). At 0.1 and 0.3 nM, endothelin reduced AA diameter by 22 +/- 6 (P less than 0.025) and 41 +/- 4% (P less than 0.001), respectively. Furthermore, endothelin provoked… CONTINUE READING

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