Direct versus Indirect Allorecognition: Visualization of Dendritic Cell Distribution and Interactions During Rejection and Tolerization

  title={Direct versus Indirect Allorecognition: Visualization of Dendritic Cell Distribution and Interactions During Rejection and Tolerization},
  author={J. Ochando and N. Krieger and J. Bromberg},
  journal={American Journal of Transplantation},
Interactions of donor and recipient dendritic cells (DCs) with CD4+ T cells determine the alloantigenic response in organ transplantation, where recipient T cells respond either directly to donor MHC, or indirectly to processed donor MHC allopeptides in the context of recipient MHC molecules. The present study evaluates donor and recipient alloantigen‐presenting DC trafficking and their interactions with CD4+ T cells in the lymph nodes (LNs) and the spleen under tolerogenic treatment with anti… Expand
47 Citations
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  • Biology, Medicine
  • Transplantation
  • 2016
Divergent role of donor dendritic cells in rejection versus tolerance of allografts.


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Inability to Induce Tolerance Through Direct Antigen Presentation
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  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2002
Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation.
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Frontline: Peripheral priming of alloreactive T cells by the direct pathway of allorecognition
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts